Whether nodes are activated by right clicking or left clicking is very inconsistent between mods. For example, mesecon switches usually are activated by left clicking, but things like doors are opened by right click.
Personally, I like using right click, because it makes more sense, and you can break the node without activating it (for example, if you want to break a mesecon lever, you end up turning it on and off a few times)
However, sometimes when holding shift to place a node on something that is activated by right clicking (like a chest), the node that I place is facing the wrong way...
Also, in creative when I'm flying, I have to put blocks under me so I can hold shift without falling.

